Faculty Directory

Sriram, Ganesh

Sriram, Ganesh

Associate Professor
Keystone Professor
Associate Chair and Undergraduate Program Director
Chemical and Biomolecular Engineering
Maryland Energy Innovation Institute
4418 Stadium Dr. 1208D

EDUCATION

Ph.D., Iowa State University, 2004

BACKGROUND

Dr. Ganesh Sriram is Keystone Assistant Professor in the Department of Chemical and Biomolecular Engineering and Affiliate Faculty Member in the Bioengineering and Plant Biology graduate programs at University of Maryland. After earning his bachelor's and master's degrees in chemical engineering from Indian Institute of Technology (IIT) Bombay, he graduated a Ph.D. in chemical engineering from Iowa State University in 2004, working in the lab of Dr. Jacqueline Shanks. From 2004 to 2007, he was a postdoctoral researcher in the labs of Dr. Katrina Dipple and Dr. James Liao at UCLA.

HONORS AND AWARDS

  • Keystone Professorship, A. James Clark School of Engineering, University of Maryland, 2011
  • Outstanding Young Engineer Award and Allan C. Davis Medal, Maryland Academy of Sciences and Maryland Science Center, 2011
  • Minta Martin Award, A. James Clark School of Engineering, University of Maryland, 2008
  • Samuel Roberts Noble Foundation Best Presentation Award, Third International Congress on Plant Metabolomics, 2004
  • Metabolic Engineering III Fellowship, Engineering Conferences International, 2000
  • Best Innovative Potential Master’s Thesis Award, Indian National Academy of Engineering, 1999 (Conferred by the Prime Minister of India)
  • Young Scientist Award for Best Research Paper, International Congress for Sustainable Development of Environment, 1997

PROFESSIONAL MEMBERSHIPS

  • Sigma Xi, The Scientific Research Society
  • American Institute of Chemical Engineers
  • American Chemical Society
  • American Society of Plant Biologists

 

Systems biology and metabolic engineering (metabolic networks, regulatory networks, fuel production from biorenewable resources); genetically inherited metabolic disorders.


The Sriram Lab's research is focused on two related areas: metabolic engineering and systems biology, especially of eukaryotes. The group's  specialties are metabolic flux analysis and gene regulatory network analysis. Toward performing such analyses, the group combines experimental methods such as isotope labeling, two-dimensional (2-D) NMR, gas chromatography-mass spectrometry (GC-MS), DNA microarray analysis and quantitative RT-PCR (qPCR) together with computational methods.

For more information, please visit Professor Sriram's web site.

Professor Sriram currently teaches or has taught the following courses:

  • BIOE 120: Biology for Engineers
  • CHBE100: Exploring ChBE (Co-Instructor)
  • CHBE101/ENCH 215: Introduction to Chemical and Biomolecular Engineering
  • CHBE301/ENCH 300: Chemical Process Thermodynamics
  • CHBE444: Process Economics and Design I
  • CHBE484/ENCH 468M/BIOE 489L/ENCH648M: Metabolic Pathway Engineering

  • Zheng Y§, Quinn AH§, Sriram G. Experimental evidence and isotopomer analysis of mixotrophic glucose metabolism in the marine diatom Phaeodactylum tricornutum. Microbial Cell Factories 12: 109. (§These authors contributed equally and are listed in the order in which they joined the project.) View at publisher (OPEN ACCESS)
  • Misra A, Sriram G. Network component analysis provides quantitative insights on an Arabidopsis transcription factor-gene regulatory network. BMC Systems Biology 7: 126. View at publisher (OPEN ACCESS) (Highly Accessed)
  • Misra A, Conway MF, Johnnie J, Qureshi TM, Derrick AM, Agbo EC, Sriram G. (2013) Metabolic analyses elucidate nontrivial gene targets for amplifying dihydroartemisinic acid production in yeast. Frontiers in Microbiology, 4: 200. View at publisher (OPEN ACCESS)
  • Nargund S, Sriram G (2013) Designer labels for plant metabolism: Statistical design of isotope labeling experiments for improved quantification of flux in complex plant metabolic networks. Molecular BioSystems 9: 99-112. View at publisher
  • Alper HS, Cirino PC, Nevoigt E, Sriram G (2010) Applications of synthetic biology in microbial biotechnology. Journal of Biomedicine and Biotechnology (now BioMed Research International), article ID 918391, 2 pages. Guest editorial (invited but not peer-reviewed). View at publisher (OPEN ACCESS) (non-peer reviewed editorial)
  • Zheng Y, Sriram G (2010) Mathematical modeling: bridging the gap between concept and realization in synthetic biology. Journal of Biomedicine and Biotechnology (now BioMed Research International) article ID 541609, 16 pages. View at publisher (OPEN ACCESS)
  • Sriram G, Rahib L, Parr LS, Liao JC, Dipple KM (2010) Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells. Metabolic Engineering 12:332-340. View at publisher View at PMC (OPEN ACCESS)
  • Rahib L, Sriram G, Harada MK, Liao JC, Dipple KM (2009) Transcriptomic and network component analysis of glycerol kinase in skeletal muscle using a mouse model of glycerol kinase deficiency. Molecular Genetics and Metabolism 96:106-112. View at publisher View at PMC (OPEN ACCESS)
  • Iyer VV, Sriram G, Fulton DB, Zhou R, Westgate ME, Shanks JV (2008) Metabolic flux maps: An effective tool for studying the effect of temperature on protein and oil biosynthesis in developing soybean cotyledons. Plant, Cell, and Environment 31:506-517. View at publisher (OPEN ACCESS)
  • Sriram G, Rahib L, He J-S, Campos AE, Liao JC, Dipple KM (2008) Global metabolic changes due to glycerol kinase overexpression in rat liver cells. Molecular Genetics and Metabolism 93:145-159. View at publisher View at PMC (OPEN ACCESS)
  • Sriram G, Iyer VV, Fulton DB, Shanks JV (2007) Identification of hexose hydrolysis products in metabolic flux analytes: A case study of levulinic acid in plant protein hydrolysate. Metabolic Engineering 9: 442-451. (Cover article) View at publisher
  • Sriram G, Fulton DB, Shanks JV (2007) Flux quantification in central carbon metabolism of Catharanthus roseus hairy roots by 13C labeling and comprehensive bondomer balancing. Phytochemistry 68: 2243-2257. View at publisher
  • Sriram G§, González-Rivera O§, Shanks JV (2006) Determination of biomass composition of Catharanthus roseus hairy roots for metabolic flux analysis. Biotechnology Progress 22: 1659-1663. §Equally contributing authors. View at publisher
  • Sriram G, Martinez JA, McCabe ERB, Liao JC, Dipple KM (2005) Single-gene disorders: What role could moonlighting enzymes play? American Journal of Human Genetics 76: 911-924. View at publisher View at PMC (OPEN ACCESS)
  • Sriram G, Fulton DB, Iyer VV, Peterson JM, Zhou R, Westgate ME, Spalding MH, Shanks JV (2004) Quantification of compartmented metabolic fluxes in developing soybean embryos by employing biosynthetically directed fractional 13C labeling, two-dimensional [13C, 1H] nuclear magnetic resonance, and comprehensive isotopomer balancing. Plant Physiology 136: 3043-3057. View at publisher (OPEN ACCESS) Featured in Faculty of 1000 Biology
  • Sriram G, Shanks JV (2004) Improvements in metabolic flux analysis using carbon bond labeling experiments: bondomer balancing and Boolean function mapping. Metabolic Engineering 6: 116-132. View at publisher

Maryland Energy Innovation Institute Awards Three Energy Fellowships

New innovations in sustainable energy storage and generation awarded

Hu, Leite Named Outstanding Engineer and Scientist of the Year (VIDEO)

Materials Science professors receive awards from the Md. Academy of Sciences and Md. Science Center.

2012 Energy Research Fellows Announced

Awards will fund diverse sustainable energy research projects

Poplar Tree Biofuel Project: Front Page News!

Sriram, Coleman featured in May 3 issue of The Baltimore Sun.