Event
MSE Seminar: Dr. Edwin Pozharski, UMD
Wednesday, October 7, 2026
3:30 p.m.
Room 2108 Chemical and Nuclear Engineering Building
Sherri Tatum
301-405-5240
statum12@umd.edu
Ask what CryoEM can do for you
Abstract: Modern cryoelectron microscopy achieves atomic resolution of biomacromolecules by use of high speed electron counting detectors, overcoming the blurring of the microscopic images due to mechanical instabilities and beam induced motions. Examples of the structural biology applications of these techniques are discussed that include antigen recognition by antibodies, molecular mechanisms of toxicity of bacterial pathogens and high resolution characterization of biomaterials. Experimental capabilities of the CryoEM center at the University of Maryland Institute for Bioscience and Biotechnology Research are introduced.
Bio: Dr. Pozharski's area of scientific expertise is structural biology, with a major focus on protein X-ray crystallography. Throughout his career as a protein crystallographer, Dr. Pozharskiy has focused on structural mechanisms of molecular recognition in a range of biomolecular systems, including small molecules, protein-DNA, and protein-protein interactions. He has also contributed to methodological aspects of protein crystallography, including computational methods, structure validation, and crystallization methods. As a molecular biophysicist, Dr. Pozharskiy has expertise in membrane biophysics and protein thermodynamics, including the study of cationic lipids and their DNA complexes. He utilizes a variety of biophysical techniques, such as dynamic light scattering, protein fluorescence and fluorescence anisotropy, differential scanning fluorimetry, and isothermal titration calorimetry.
